Young Chemical Biologists’ Forum(Auditorium)

Chairs: Xiaoguang Lei,  ICBS2013 YCB, Peking   University

Qi  Zhang, Fudan University

Women Chemical Biological Scientist forum

(Conference Room)

Chairs: Zaneta Nikolovska-Coleska, University of Michigan,USA

Xu  Zhang, Nanjing University  of Chinese Medicine

8:30-8:50    A shotgun Approach to inquire  degradable

kinome

Li  Tan, Shanghai Institute  of Organic Chemistry, Chinese Academy    of Sciences,China

8:50-9:10     XFEL for structural chemical biology of

           GPCRs

Haitao Zhang, Zhejiang  University,China

9:10-9:40    Exploring Complex Protein  Structures and

           Protein-Protein  Interactions with CXMS

Xiaoguang  Lei  (YCB2013), Peking University,China

9:40-10:00   Chemoproteomic Profiling Reveals the Anti

steatosis Mechanism of Traditional Chinese

Medicine

Chu Wang, Peking University,China

8:30-9:00    Enzyme and Pathway Design for Efficient

           Biosynthesis

Yan Feng,Shanghai Jiao Tong University,China

9:00-9:30     Mechanistic investigation of herbal

            medicine and compounds on NSCLC

Xu Zhang, Nanjing University  of Chinese Medicine,China

9:30-10:00    Physiologically relevant 3D  model system for chemical biology screening

Yuhong Du, Emory  University School of Medicine,USA

10:00-10:15  Coffee  Break

10:15-10:45   Small-molecule stabilization of protein

   protein interactions

Christian Ottmann (YCB2013), Eindhoven University of Technology,Netherlands

10:45-11:05   Biosynthesis  of PP2A inhibitor Rubratoxin A

Youcai Hu, Institute of Materia Medica,

Chinese Academy of Medical    Sciences & Peking Union Medical College,China

11:05-11:35  Regulation and targeting of  BAX-mediated

           apoptosis

Evripidis  Gavathiotis (YCB2014), Albert Einstein College of Medicine, USA

11:35-11:55  Mechanistic Studies of a Multifunctional 2-         Oxoglutarate  Dependent Non-heme Iron

             Enzyme, AsqJ                                       

            Yisong Guo, Carnegie Mellon University,USA

11:55-12:10   5M strategy guided metabolic  engineering

of high-yield  Rhodobacter Sphaeroides for

co-enzyme Q10  overproduction

Gaoyi Tan, East China   University of

Science and Technology,China

10:15-10:45   Zaneta  Nikolovska-Coleska, University of Michigan,USA

10:45-11:00   Fragment  Based Approaches Towards

the Development of CoaBC Inhibitors as

Novel Antimicrobial  Drugs

Jeannine Hess, Department of

Chemistry,University of Cambridge,UK

11:00-11:15    Sequential deletions of the  chromosome I of Saccharomyces cerevisiae by

constructing a small chromosome

Min Zhou, Shanghai Institutes for

Biological Science,China

11:15-11:30   Downregulation of Kinase by  ATP-competitive Kinase inhibitors

Li Jing, Pfizer Inc,USA

11:30-11:45   Decipher and  harnessing of the programmed triacylglycerols bridge for titer improvement of  polyketides in Streptomyces

             Shanshan Li, Institute of Plant                               Protection,Chinese Academy  of Agricultural    Sciences

11:45-12:00   Genomic Insights into Diversity of TPS and the Terpenoids of Pathogenic Fungi

Jingyu Zhang, EastChinaUniversity of

Science  and Technology,China

12:00-13:20  Lunch  (posters by odd number/exhibition session)

13:20-13:40   Protein  chemical Synthesis for further      ubiquitin code and histone  ubiquitin code    

analysis    

Changlin Tian,School of Life Sciences, University  of Science and Technology ofChina,China

13:40-14:00   Mechanistic  investigation of radical S-     adenosylmethionine enzymes

Qi Zhang, Fudan University,China

14:00-14:30    Development  of far-red to near-infrared

            small-molecules fluorophores and their  application to fluorescent probes

Kenjiro  Hanaoka (YCB2014), The University of Kokyo,Japan

14:30-14:45   Coffee Break

14:45-15:15 Electrophysiology,  Unplugged: Using     Chemistry  to Watch Cells in Action

Evan Miller (YCB2015), University of California- Berkeley,USA

15:15-15:45   Inspiration from  Fluorination:  Chemical

           Biology  Approaches to Probe Molecular

Recognition  Events in Transcription

William Pomerantz (YCB2016), University of Minnesota Twin Cities,USA

15:45-16:20  Group Photo (The Great  Lawn)

            NOTE: Raining  day upon notice

16:20-17:00  Welcome Speeches

Chair: Lixin Zhang, ECUST

17:00-17:45  Opening Keynote address

Chemical  Biology of DNA modifications by sulfur

Zixin Deng, Shanghai Jiao  Tong University,  Shanghai,China;

17:45-18:45  Podium flash  presentations from selected posters

Chair: Tom Pfeifer, CDRD,Canada

19:00-21:00  Welcome Reception (Pullman, 1 Pubei Road, Xuhui District)

8:30-11:15    ICBS  President’s forum and Round table discussion(Auditorium)

Synthetic  Biology to drive chemical biology and biotechnology

Chairs: Jens Nielsen and George Guo-Qiang CHEN

8:30-8:45     Sang  Yup Lee,KoreaAdvanced Institute of Science and Technology,Korea

8:45-9:00     Next  Generation Industrial Biotechnology based on Halophiles

George  Guo-Qiang Chen, Tsinghua University,China

9:00-9:15     Synthetic  biology of yeast for production of fuels and chemicals

Jens  Nielsen, Chalmers University of Technology,Sweden

9:15-9:30     Harnessing  synthetic biology for fine and speciality chemical production

Eriko  Takano, University of Manchester,UK

9:30-9:45     Engineering  of Optogenetic Designer Human Cells for Diabetes Therapy

Haifeng  Ye, East China Normal University,China

9:45-11:30    Panel discussion on  Development of Commercialization of Synthetic Biology

11:30-13:00   Lunch (Posters by odd number/exhibition session/State Key  Laboratory of Bioreactor Engineering tour)

I.           Chemical innovations to  expand chemical space and reach the undruggables

Session  1: Expand the chemical space (Auditorium)

Chairs: Jason Micklefield, The University of  Manchester, UK

Huw Davies, Emory University,USA

13:00-13:25  Mechanistic studies of the cyclization reactions in the  biosynthesis of spinosyn

            Hung-wen (Ben) Liu, University of  Texas at Austin,USA

13:25-13:50  Heterologous Expression of a Large-sized Natural Product  Biosynthetic Gene Cluster in Streptomyces

            Eung-Soo Kim, Inha    University,South Korea

13:50-14:15  Diversification of bioactive natural and non-natural products using  engineered biosynthetic pathways

            and enzymes

Jason  Micklefield,  The University of Manchester,UK

14:15-14:40  Genetically encoding phosphotyrosine and its  nonhydrolyzable analog

            Feng Wang,  California Institute for Biomedical Research,USA

14:40-15:05  Beyond  orthogonality, another good reaction for click chemistry

            Jiajia Dong,  Shanghai Institute of Organic Synthesis,China

15:05-15:30  Collaborative approaches for selective C-H functionalization

            Huw Davies, Emory    University,USA

15:30-15:45  Coffee  Break

Session 2: New chemical modalities (Auditorium)

Chairs: Xiyun Yan, Institute of Biological Physics, Chinese

Academy of Sciences,China

      Zhen  Xi, Nankai University,China

Session 3: Chemical biology to address undruggable targets (Conference Room)

Chairs:    Tom Pfeifer, CDRD,Canada

Jiangyun  Wang, Institute  of Biophysics, Chinese Academy of Sciences,China

15:45-16:10   Nanozyme: discovery and its applications

             in medicine

Xiyun Yan, Institute  of Biological Physics, Chinese Academy of Sciences,China

16:10-16:35   Chemoenzymatic glycan  labeling:

             methods and applications

Peng  Wu, John Hopkins University,USA

16:35-17:00    MetDNA:  Recursive Metabolite

             Annotation  and Dysregulated Network Analysis for Untargeted Metabolomics

Zhengjiang  Zhu, Shanghai Institute of Organic Chemistry,China

17:00-17:25   Ribosome pausing at AT-rich  codons

             regulates  translation in Streptomyces

tsukubaensis

Byung-Kwan Cho,KoreaAdvanced Institute of Science  and Technology (KAIST), Republic   of Korea

15:45-16:10  Targeting  E2/E3 ubiquitin ligase activity as

            a novel strategy to combat autoimmunity

Kamyar Hadian,  Helmholz-Zentrum munchen,Germany

16:10-16:35  Metalloprotein  design using genetic code

            expansion

Jiangyun Wang, Institute of Biophysics, Chinese Academy of Sciences,China

16:35-17:00   Chemical  intervention of RNA methylation

            Caiguang Yang, Shanghai Institute of

Material Medica,China

17:00-17:15  Therapeutic strategies to target tumor suppressors through protein  interaction network

Andrei Ivanov, Emory University,USA

17:15-17:30  Fluorogenic, Bioorthogonal  Reactions of

Heterodienes for Bioimaging  Applications

Milan Vrabel, IOCB, AS CR, Czech

Republic

17:30-18:30   Posters by odd number/exhibition  session

18:30-20:00   Dinner (Youyi restaurant)

II.         Addressing challenges in  diseases with chemical biology

8:30-9:15    Keynote address (Auditorium)

Expanding antibiotic  chemical space baed on bacterial biodiversity to fight antimicrobial  resistance

Rolf  Müller,Helmholtz Institute for Pharmaceutical  Research Saarland (HIPS),Germany

Session 4: Determine  molecular mechanisms of an active compound (Auditorium)

Chair: Bridget Wagner,  Broad Institute of MIT and Harvard,USA

Seung Bum Park, Seoul    National University,South Korea

9:15-9:40    Systematic approaches to small-molecule

            mechanism-of-action studies

Bridget Wagner, Broad Institute of MIT and Harvard,USA

9:40-10:05   Screening  and target identification of small molecules affecting cancer metabolism

            Hiroyuki Osada, RIKEN,Japan

10:05-10:30  FITGE-based Target Identification: New  Tool in Chemical Biology

            Seung Bum  Park, Seoul National University,Korea

10:30-10:45  Coffee Break

10:45-11:10  Function of CDK1-TIP60-Aurora  B axis in

            cellfate decision  control

Xuebiao Yao, University  of Science and Technology ofChina

11:10-11:25  Chemical Proteomics Reveal Bioactive  Mechanism of Natural Products through Activity-based Protein

Profiling Strategy

Youli Xiao, CAS Key Laboratory of Synthetic Biology, CAS Center for  Excellence in Molecular

11:25-11:40  Novel mechanism of action of an anti-biofilm antibiotic

Chengzhang Fu, Helmholtz Institute for

Pharmaceutical Research Saarland

(HIPS),Germany

11:40-11:55  Resistance  Mechanisms to mTOR Kinase Inhibitors in Cancer

X.F. Steven Zheng,Rutgers  Cancer Institute of New Jersey,USA

11:55-12:10  Fueling metabolism one reaction at a time

Zongbao Kent Zhao, Dalian  Institute of Chemical Physics,China

10:45-12:00 Global  chemical biology landscape – an update(Conference Room)

Chair: Masatoshi Hagiwara, University of Kyoto,Japan

The Japanese Society for Chemical Biology

Masatoshi  Hagiwara, University of Kyoto,Japan

Chemical biology inChina

Lihe  Zhang, Peking University,China

Graduate Chemical Biology education in  theUS

Zaneta  Nikolovska-Coleska, University of Michigan,USA

EU-OpenScreen and chemical  biology in Europe

Bahne  Stechmann, EU-OPENSCREEN, Berlin,Germany

Updates on chemical biology societies and  activities around the globe

12:00-13:30   Lunch (Posters by even  number/exhibition session)

13:30-14:15   Keynote address (Auditorium)

RNA-targeting  chemical therapeutics

Masatoshi  Hagiwara, Kyoto    University,Japan

Session 5: Interrogate  diseases with chemical biology Ⅰ(Auditorium)

Chairs: Guo-Qiang Chen, Shanghai Jiaotong University,China

              Jonathan Baell, Monash University,Australia

Session 6:  Interrogate diseases with chemical biology Ⅱ (Conference Room)

Chairs:  Hanne Ingmer, University of  Copenhagen,

Denmark

Cong Liu, Shanghai Institute of Organic  Chemistry, China

14:15-14:40  Cancer cell fate determination-based

            chemical biology investigation

Guo-Qiang Chen, Shanghai Jiaotong University,China

14:40-15:05  Discovery of first-in-class specific small

            molecules antagonizing PXR(NR112) to overcome drugresistance in human cancers

Taosheng  Chen, St Jude Children’s Research Hospital,USA

14:15-14:40   A general methodology for conversion of

             life-threatening viruses  into live virus vaccines

Demin  Zhou, Peking University,China

14:40-15:05   Interplay between a-synuclein and lipid

             in Parkinson’s disease

Cong Liu, Shanghai Institute of Organic

Chemistry,China

15:05-15:20  Coffee  Break

15:20-15:45  Novel small molecule  MerTK inhibitors

            and their dual  function in cancer treatment

Xiaodong Wang, The University of North   Carolina at Chapel    Hill,USA

15:45-16:10  Spatiotemporal control  cellular functions      by environment  stimuli-induced proximity

Wei Wang, East China   University of

Science and Technology,China

16:10-16:35  Design and development of

           slycosyltransferase inhibitors as novel anti

metastaticagents

Danielle Skropeta, University of    Wollongong,Australia

16:35-17:00  Aglycone polyethers J1-001  and its homologues are effective to broad cancer cells

Tiangang Liu, Wuhan University,China

17:00-17:15   Identification and functional

characterization of novel xylose

transportersfrom Trichoderma reesei

Xu Fang, Shandong University,China

17:15-17:35  Identifying miRNAs that  influence cancer cell growth and chemotherapeutic sensitivity

Robert (Bob) Lund,  BeckMan Coulter

15:20-15:45    Natural quorum quenching compounds

              targeting Staphylococcus aureus quorum  sensing- implications for colonization and infection

Hanne Ingmer, University of Copenhagen,Denmark

15:45-16:00    Protein  aggregation small molecule

inhibitordiscovery and mechanisms

Bin Xu, School of Neuroscience, Virginia  Tech,USA

16:00-16:15   Cytotoxic protein from the mushroom Coprinus  comatus possesses a unique glycan binding fold and specificity

Yousong Ding, University of Florida,USA

16:15-16:30  Generation of click-able kirromycin  derivatives by exploiting the substrate promiscuity of the discrete acyl  transferase KirCII

Tilmann Weber, Technical University of

Denmark,Denmark

16:30-17:30  Special  session: Chemical  biology in pharmaceutical industry (Conference Room)

Chair:    Christian Ottmann, Eindhoven University    of Technology,Netherlands

Panelists: Yves  Auberson, Novartis,Switzerland

Rathnam Chaguturu, iDDPartners,USA

Hong Shen, Roche    Innovation Center,China

Takashi Owa, Eisai Co., Ltd.,Japan

Yanwen Liu, SPRIM China  Company, USA

17:30-18:30   Posters by even number/exhibition session

18:30-20:00   Dinner (Youyi restaurant)

III.       Chemical  biology innovations and applications

Session 7:Biological insights with  chemical biology (Auditorium)

Chairs:Tapas Kundu, JCASR,India

Siddhartha Roy, Boss Institute,India

Session 8: Molecular biosensors and actuators (Conference Room)

Chair:       Jin Zhang, University of  California San Diego,USA

8:30-8:55     Protein degradation based conditional

             knockout

Pinghua Liu, Boston    University,USA

8:55-9:20     Crosstalk between epigenetic systems in

             bacteria

Shi Chen, Wuhan University,China

9:20-9:45     Chemical-assisted sequencing of

             epigenetic nucleic acid modifications

Chengqi  Yi, Peking University,China

9:45-10:10    Structural insights of  electron transfer

              in P450 monooxygenase

Jiahai Zhou,Shanghai Institute of Organic Chemistry,China

8:30-8:55    NIR Fluorescent Organic  Nanoprobes

            Weihong Zhu, EastChinaUniversity  of Science and Technology,China

8:55-9:20    Making gels in cells: total  synthesis of

            stress granules by multivalent enhancers

Takanari  Inoue, Johns Hopkins University,USA

9:20-9:45    Protein engineering and the  development

            of intracellular biosensors

Robert Campbell, University of Alberta,

Canada

9:45-10:10   Genetically encoded fluorescent sensors

            reveal dynamic  regulation of redox metabolism in living cells

Yi Yang, EastChinaUniversity of Science

AndTechnology,China

10:10-10:20  Coffee Break

Session 9:Emerging technologies (Auditorium)

Chairs: Mikiko Sodeoka, RIKEN,Japan

Peng  Chen, Peking University,China

Session 10: Computational approaches to accelerate chemical  biology research (Conference  Room)

Chairs: Luhua Lai, Peking University,China

Petr  Bartunek,  Institute of Molecular Genetics,Czech Republic

10:20-10:55    Bioorthogonal cleavage  reactions in

              living cells

Peng Chen, Peking    University,China

10:55-11:20   Perturbation of microtubule  function

              using designed peptides

Surajit  Ghosh, CSIR-IICB,India

11:20-11:35   Structural investigations on  multiple steps of viral DNA cytidine deamination

              Chunyang Cao, Institute  of Organic Chemistry, University of Chinese  Academy of Sciences

11:35-11:50   Selective labelling and eradication of  antibiotic-tolerant populations in bacterial biofilms

Liang  Yang, Nanyang Technological

University, Singapore

11:50-12:15    Turn-on fluorescent labeling using O

             NBD unit

Mikiko Sodeoka, RIKEN,Japan

10:20-10:50   Chemical and  biological space exploration

             Petr Bartunek, Institute of Molecular Genetics,Czech    Republic

10:50-11:15     Rational  design of protein allosteric

            regulators

Luhua Lai, Peking UniversityChina

11:15-11:40   Evolution of chemical  similarity: from

             structure to activity

Paul A. Clemons, Broad Institute of MIT and Harvard,USA

11:40-11:55 Antimicrobial  Nylon-3 Polymers as Synthetic Mimics of Host Defense Peptide

Runhui Liu,East ChinaUniversity  of Science and Technology,China

12:00-13:30   Lunch

13:30-14:30  Rising stars in chemical  biology: ICBS Young Chemical Biologist awards  2017 (Auditorium)

Chair: Haian  Fu, Emory University,USA

14:30-15:15  Closing Keynote address (Auditorium)

Biological applications of SuFEX click  chemistry

K. Barry Sharpless, 2001 Nobel Prize in Chemistry, The Scripps Research Institute, La  Jolla, USA

15:15-16:00  ICBS Business meeting (Auditorium)

16:00-  Shuttle bus to the Bund

17:30-21:00  Banquet,  award and performance (The Bund 22, Huangpu District)