Part I: 8:30- 16:00  Young Chemical Biologists’ Forum

Chairs: Xiaoguang Lei, ICBS2013 YCB, Peking University

Qi Zhang, Fudan University

8:30-8:50    A shotgun Approach to inquire degradable kinome

Li Tan, Shanghai Institute of Organic Chemistry,  Chinese Academy of Sciences,China

8:50-9:10     XFEL for structural chemical  biology of GPCRs

Haitao Zhang, Zhejiang  University,China

9:10-9:40    Exploring Complex Protein Structures and  Protein-Protein Interactions with CXMS

Xiaoguang Lei (YCB2013), Peking University,China

9:40-10:00   Chemoproteomic Profiling Reveals the Anti-steatosis Mechanism of  Traditional Chinese Medicine

Chu Wang, Peking University,China

10:00-10:15  Coffee  Break

10:15-10:45   Small-molecule  stabilization of protein-protein interactions

Christian Ottmann (YCB2013), Eindhoven University    of Technology,Netherlands

10:45-11:05   Biosynthesis  of PP2A  inhibitor Rubratoxin A

Youcai Hu, Institute of Materia Medica, Chinese  Academy of Medical Sciences & Peking Union Medical College,China

11:05-11:35  Regulation and targeting of BAX-mediated apoptosis

Evripidis Gavathiotis (YCB2014), Albert  Einstein College of Medicine, USA

11:35-11:55   Mechanistic  Studies of a Multifunctional 2-Oxoglutarate Dependent Non-heme Iron Enzyme,  AsqJ

Yisong Guo, Carnegie Mellon University,USA

11:55-13:20  Lunch  (poster and sponsor exhibition session)

13:20-13:40   Stimuli-responsive  nucleic acids as potential sensors and drugs

Yu Xiang, Tsinghua University,China

13:40-14:00   Mechanistic  investigation of radical S-adenosylmethionine enzymes

Qi Zhang, Fudan University,China

14:00-14:30  Development  of far-red to near-infrared small-molecules fluorophores and their  application to fluorescent probes

Kenjiro Hanaoka (YCB2014), The University of Kokyo,Japan

14:30-14:45  Coffee  Break

14:45-15:15   Electrophysiology,  Unplugged: Using Chemistry to Watch Cells in Action

Evan Miller (YCB2015), University of    California- Berkeley,USA

15:15-15:45   Inspiration  from Fluorination:  Chemical Biology  Approaches to Probe Molecular Recognition Events in Transcription

William Pomerantz (YCB2016), University of Minnesota    Twin Cities,USA

16:00-17:00   Welcome Speeches (including Group  Photo)

Chair: Lixin Zhang, ECUST

17:00-17:45  Opening scientific presentations

Chemical Biology of DNA  modifications by sulfur

Zixin  Deng, Shanghai  Jiao Tong  University, Shanghai,China;  Title: Chemical Biology of S modifications

17:45-18:45  Podium flash presentations for selected  poster presentations

Chair: Tom Pfeifer, CDRD,Canada

19:00-21:00  Welcome Reception (Jinshayugang grand  hotel, 400 Tiandeng Road,  Xuhui District)

8:30-11:15    ICBS President’s forum and Round table discussion

Synthetic Biology to drive chemical biology  and biotechnology

Chairs: Jens Nielsen  and George Guo-Qiang CHEN

8:30-8:45     Sang  Yup Lee,KoreaAdvanced Institute of Science and Technology,Korea

8:45-9:00     Next Generation Industrial Biotechnology  based on Halophiles

George Guo-Qiang Chen, Tsinghua    University,China

9:00-9:15     Synthetic  biology of yeast for production of fuels and chemicals

Jens Nielsen, Chalmers University of Technology,Sweden

9:15-9:30      Harnessing  synthetic biology for fine and speciality chemical production

Eriko Takano, University    of Manchester,UK

9:30-9:45     Engineering of  Optogenetic Designer Human Cells for Diabetes Therapy

Haifeng Ye, East    China Normal University,China

9:45-11:15    Panel discussion on  Development of Commercialization of Synthetic Biology

11:15-11:45   ICBS2017 business meeting

11:45-13:00   Lunch (State Key  Laboratory of Bioreactor Engineering visiting and sponsor exhibition session)

I.           Chemical  innovations to expand chemical space and reach the undruggables

Session 1: Expand the chemical space

Chairs: Jason  Micklefield, The University of  Manchester, UK

Huw Davies, Emory University,USA

13:00-13:25   Mechanistic  studies of the cyclization reactions in the biosynthesis of spinosyn

Hung-wen (Ben) Liu, University  of Texas at Austin,USA

13:25-13:50   Heterologous  Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in  Streptomyces

Eung-Soo Kim, Inha    University,South Korea

13:50-14:15  Diversification of bioactive natural and non-natural products using  engineered biosynthetic pathways and enzymes

Jason Micklefield, The University of Manchester,UK

14:15-14:40  Genetically encoding phosphotyrosine and its nonhydrolyzable analog

Feng Wang, California Institute for Biomedical Research,USA

14:40-14:55  Coffee  Break

14:55-15:20   Beyond orthogonality, another  good reaction for click chemistry

Jiajia Dong, Shanghai Institute of Organic Synthesis,China

15:20-15:45   Collaborative  approaches for selective C-H functionalization

Huw Davies, Emory    University,USA

Session 2: Chemical biology to address undruggable targets

Chairs:    Tom Pfeifer, CDRD,Canada

Jiangyun Wang, Institute of Biophysics,  Chinese Academy of Sciences,China

15:45-16:10  Targeting  E2/E3 ubiquitin ligase activity as a novel strategy to combat autoimmunity

Kamyar  Hadian, Helmholz-Zentrum munchen,Germany

16:10-16:35  Metalloprotein  design using genetic code expansion

Jiangyun Wang, Institute of Biophysics,  Chinese Academy of Sciences,China

16:35-17:00  Therapeutic strategies to target tumor suppressors through protein  interaction network

Andrei Ivanov, Emory University,USA

Session 6: Computational  approaches to accelerate chemical biology research

Chairs: Luhua Lai,  Peking University,China

Petr Bartunek,  Institute of Molecular Genetics,Czech Republic

15:45-16:15  Chemical  and biological space exploration

Petr Bartunek,  Institute of Molecular Genetics,Czech Republic(30min)

16:15-16:40   Rational design of protein  allosteric regulators

Luhua  Lai, Peking UniversityChina

16:40-17:05   Evolution of chemical similarity: from structure to  activity

Paul A. Clemons, Broad Institute of MIT and Harvard,USA

17:05-18:20   Poster session

II.         Addressing  challenges in diseases with chemical biology

8:30-9:15    Keynote  talk

Expanding antibiotic chemical  space baed on bacterial biodiversity to fight antimicrobial resistance

Rolf  Müller,Helmholtz Institute  for Pharmaceutical Research Saarland (HIPS),Germany

Session 3: Determine molecular mechanisms of an active compound

Chair: Bridget Wagner, Broad Institute of  MIT and Harvard,USA

Seung Bum Park, Seoul    National University,South Korea

9:15-9:40    Systematic approaches to small-molecule  mechanism-of-action studies

Bridget Wagner, Broad Institute of MIT and Harvard,USA

9:40-10:05   Screening  and target identification of small molecules affecting cancer metabolism

Hiroyuki Osada, RIKEN,Japan

10:05-10:30  FITGE-based  Target Identification: New Tool in Chemical Biology

Seung Bum Park, Seoul National University,Korea

10:30-10:45  Coffee Break

Session 3: Determine molecular mechanisms of an active compound

Chair: Bridget Wagner, Broad Institute of  MIT and Harvard,USA

Seung Bum Park, Seoul National University,South Korea

10:45-12:05

Special session: Chemical  biology in pharmaceutical industry

Chair:   Christian  Ottmann, Eindhoven University of Technology,Netherlands

Panelists: Yves  Auberson, Novartis,Switzerland

Rathnam  Chaguturu,  iDDPartners,USA

Hong  Shen, Roche Innovation Center,China

Takashi Owa, Eisai  Co., Ltd.,Japan

Yanwen Liu, SPRIM,USA 

10:45-11:10  Resistance  Mechanisms to mTOR Kinase Inhibitors in Cancer

X.F. Steven Zheng, Rutgers Cancer Instituteof New Jersey,USA

11:10-11:35  Function  of CDK1-TIP60-Aurora B axis in cell fate decision control

Xuebiao  Yao, University  of Science and Technology ofChina

11:35-11:50  Chemical Proteomics Reveal Bioactive Mechanism  of Natural Products through Activity-based Protein

Profiling Strategy

Youli Xiao, CAS  Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular

11:50-12:05  Novel mechanism of action of an anti-biofilm  antibiotic

Chengzhang Fu, Helmholtz Institute for

Pharmaceutical  Research Saarland

(HIPS),Germany

12:05-13:30    Lunch (State Key  Laboratory of Bioreactor Engineering visiting and sponsor exhibition session)

13:30-14:15   Keynote  talk

RNA-targeting chemical therapeutics

Masatoshi  Hagiwara, Kyoto    University,Japan

Session 4: Interrogate diseases with chemical biology Ⅰ

Chairs: Guo-Qiang Chen, Shanghai Jiaotong University,China

              Jonathan Baell, Monash University,Australia

Session 5: Interrogate diseases with  chemical biology Ⅱ

Chairs: Hanne  Ingmer, University of Copenhagen,

Denmark

Cong Liu, Shanghai Institute of Organic Chemistry, China

14:15-14:40 Cancer  cell fate determination-based chemical biology investigation

Guo-Qiang  Chen, Shanghai Jiaotong University,China

14:40-15:05 Design and  development ofslycosyltransferase inhibitors as novel anti-metastaticagents

Danielle  Skropeta, University    of Wollongong,Australia

14:15-14:40   A general methodology for conversion of  life-threatening viruses into live virus vaccines

Demin Zhou, Peking    University,China

14:40-15:05   Natural quorum quenching compounds targeting Staphylococcus aureus quorum  sensing- implications for colonization and infection

Hanne Ingmer, University   of Copenhagen,

Denmark

15:05-15:20  Coffee Break

15:20-15:45  Discovery  of first-in-class specific small

molecules antagonizing PXR(NR112) to overcome drugresistance in human cancers

Taosheng  Chen, St Jude Children’s Research Hospital,USA

15:45-16:10  Novel small  molecule MerTK inhibitors and their dual function in cancer treatment

Xiaodong  Wang, The University  of North Carolina at Chapel Hill,USA

16:10-16:35   Aglycone polyethers J1-001 and its homologues are effective  to broad cancer cells

Tiangang  Liu, Wuhan    University,China

16:35-16:55  Identifying miRNAs that influence cancer cell  growth and chemotherapeutic sensitivity

BeckMan Coulter

15:20-15:45   Interplay  between a-synuclein and lipids in Parkinson’s disease

Cong Liu, Shanghai Institute of Organic Chemistry,China

15:45-16:10   Protein aggregation small molecule inhibitordiscovery and mechanisms

Bin Xu, School of Neuroscience, Virginia Tech, USA (非邀请)

16:10-16:25  Cytotoxic protein from the  mushroom Coprinus comatus possesses a unique glycan binding fold and  specificity

Yousong Ding, University of Florida,USA

16:30-17:30  Global chemical biology landscape – an  update

Chair: Masatoshi Hagiwara, University of Kyoto,Japan

The  Japanese Society for Chemical Biology

Masatoshi Hagiwara, University    of Kyoto,Japan

Chemical  biology initiatives inChina

Lihe Zhang, Peking    University,China

Graduate  Chemical Biology education in theUS

Zaneta Nikolovska-Coleska, University    of Michigan,USA

EU-OpenScreen and chemical biology in Europe

Bahne Stechmann, EU-OPENSCREEN,   Berlin,Germany

Updates  on chemical biology societies and activities around the globe

17:30-18:30

Poster session

I.           Chemical biology innovations  and applications

8:30-9:15  Keynote talk

Biological applications of  SuFEX click chemistry

K. Barry Sharpless, 2001 Nobel Prize in  Chemistry, The Scripps Research Institute, La Jolla, USA

Session 7: Molecular biosensors and  actuators

Chair:      Jin Zhang, University  of California San Diego,USA

Session 8:Biological insights with  chemical biology

Chairs:Tapas Kundu, JCASR,India

Siddhartha  Roy（原为Jonathan Baell）, Boss Institute, India

9:15-9:40    NIR Fluorescent Organic Nanoprobes

Weihong Zhu, EastChinaUniversity of Science  and Technology,China

9:40-10:05    Making gels in cells: total  synthesis of stress granules by multivalent enhancers

Takanari  Inoue, Johns Hopkins University,USA

9:15-9:40      Protein  degradation based conditional knockout

Pinghua Liu, Boston University,USA

9:40-10:05   Crosstalk  between epigenetic systems in bacteria

Shi Chen, Wuhan    University,China

10:05-10:20  Coffee Break

10:20-10:45  Protein engineering and the development of  intracellular biosensors

Robert  Campbell, University of Alberta,

Canada

10:45-11:10  Genetically encoded fluorescent sensors reveal  dynamic regulation of redox metabolism in living cells

Yi Yang, EastChinaUniversity of Science

AndTechnology,China

10:20-10:45   Chemical-assisted  sequencing of epigenetic nucleic acid modifications

Chengqi  Yi, Peking    University,China

10:45-11:10   Structural insights of electron transfer

in P450 monooxygenase

Jiahai Zhou, Shanghai Institute ofOrganic Chemistry,China

11:10-11:25  Antimicrobial Nylon-3 Polymers as  Synthetic Mimics of Host Defense Peptide

Runhui Liu,East ChinaUniversity  of Science and Technology,China

11:25-11:40    Selective labelling and eradication of antibiotic-tolerant populations  in bacterial biofilms

Liang Yang, Nanyang  Technological University, Singapore

11:40-13:00    Lunch

Session 9: New chemical  modalities

Chairs:  Xiyun Yan, Institute of Biological  Physics, Chinese

Academy of Sciences,China

      Zhen  Xi, Nankai University,China

Session  10:Emerging technologies

Chairs: Mikiko  Sodeoka, RIKEN,Japan

Peng Chen, Peking    University,China

13:00-13:25  Turn-on  fluorescent labeling using O-NBD unit

Mikiko  Sodeoka, RIKEN,Japan

13:25-13:50   Nanozyme: discovery and  its applications in medicine

Xiyun  Yan, Institute  of Biological Physics, Chinese Academy of Sciences,China

13:50-14:15   Chemoenzymatic glycan  labeling:

methods  and applications

Peng Wu, John    Hopkins University,USA

14:15-14:40   MetDNA: Recursive  Metabolite Annotation and Dysregulated Network Analysis for Untargeted  Metabolomics

Zhengjiang Zhu, Shanghai Institute of Organic    Chemistry,China

13:25-13:50    Bioorthogonal cleavage  reactions in

living cells

Peng Chen, Peking    University,China

13:50-14:15   Perturbation of microtubule function using designed  peptides

Surajit  Ghosh, CSIR-IICB,India

14:15-14:40   Chemical  intervention of RNA methylation

Caiguang Yang, Shanghai Institute of Material Medica,China

14:40-14:55   Coffee  Break

14:55-15:20   Spatiotemporal control  cellular functions by environment stimuli-induced proximity

Wei Wang, East China University  of

Science and Technology,China

14:55-15:20  Ribosome pausing at AT-rich codons regulates  translation in Streptomyces tsukubaensis

Byung-Kwan Cho,KoreaAdvanced Institute of Science and Technology (KAIST), Republic of Korea

15:20-15:35    Fluorogenic,  Bioorthogonal Reactions of Heterodienes for Bioimaging Applications

Milan Vrabel,  IOCB, AS CR, Czech   Republic

15:35-16:30  Rising stars in chemical biology: ICBS Young  Chemical Biologist awards 2017

Chair: Haian Fu, Emory    University,USA

16:30-21:00 (Bund 22,  Huangpu District)

Closing ceremony, dinner, award ceremony, and performance

Poster  sessions – ICBS best poster award selection committee

Chairs:  Jonathan Baell, Monash University,Australia